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- Document type:
- Zeitschriftenaufsatz
- Author(s):
- Eiber, M.; Martinez-Möller, A.; Souvatzoglou, M.; Rummeny, E.; Schwaiger, M.; Beer, A.; Nekolla, S.
- Title:
- Value of a Dixon based MR-PET attenuation correction sequence for the localization and evaluation of PET positive lesions
- Abstract:
- Objectives: Dixon-based MR imaging with a rapid low-resolution breathhold sequence has recently been proposed as technique for MR based attenuation correction (MR-AC) for MR-PET. In this study, the potential contribution of this sequence for anatomical correlation of PET positive lesions was evaluated compared to low-dose CT. Methods: 35 patients routinely scheduled for oncological staging underwent 18F-FDG PET/CT and a 2-point Dixon 3D VIBE T1 weighted MR sequence on a 3T clinical scanner at the same day. Two PET datasets reconstructed using attenuation maps from low-dose CT (PETAC_CT) or simulated MR based segmentation (PETAC_MR) were evaluated by two experienced readers for focal PET positive lesions. The certainty for the correlation with anatomical structures was judged in the low-dose CT and Dixon based MRI on a four-point-scale (0-3). In addition, the standardized uptake values (SUVs) for PETAC_CT and PETAC_MR were compared. Results: No significant difference could be found for all 81 PET positive lesions in low-dose CT compared to Dixon based MR concerning anatomical localization (mean 2.51±0.85 and 2.37±0.87, respectively; p=0.1909). However, CT tended to be superior for small lymph nodes, bone metastases and pulmonary nodules, while Dixon based MR proofed advantageous for soft-tissue pathologies like head/neck tumors and liver metastases. For the PETAC_CT and PETAC_MR based SUVs (mean 6.36±4.47 and 6.31±4.52, respectively) a nearly complete concordance with a highly significant correlation was found (r=0.9975, p<0.0001). Conclusions: Dixon based MR imaging for MR-AC allows for anatomical allocation of PET-positive lesions similar to low-dose CT in conventional PET/CT. Thus, this approach appears to be useful for future MR-PET for body regions not fully covered by diagnostic MRI due to potential time constraints.
- Keywords:
- MedicalImaging, CAMP,PET, PET/MR
- Journal title:
- European Journal of Nuclear Medicine and Molecular Imaging
- Year:
- 2011
- Journal volume:
- 38
- Journal issue:
- 9
- Pages contribution:
- 1691--1701
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