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Document type:
Zeitschriftenaufsatz 
Author(s):
Yu, Peng; Hahne, Hannes; Wilhelm, Mathias; Kuster, Bernhard 
Title:
Ethylene glycol improves electrospray ionization efficiency in bottom-up proteomics 
Abstract:
Liquid chromatography coupled online to nano-electrospray ionization (nESI) tandem mass spectrometry is the analytical workhorse in the field of proteome research. Dimethyl sulfoxide (DMSO) was recently shown to improve nESI efficiency by a factor of three to ten thus improving the sensitivity and coverage of proteomic experiments. However, relatively few investigations into which solvent additives promote nESI response have been performed at a proteomic scale. Here, we systematically evaluated...    »
 
Journal title:
Analytical and Bioanalytical Chemistry 
Year:
2016 
Journal volume:
409 
Journal issue:
Pages contribution:
1049-1057 
Publisher:
Springer Science and Business Media LLC 
E-ISSN:
1618-26421618-2650 
Date of publication:
20.10.2016