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Document type:
Zeitschriftenaufsatz
Author(s):
Médard, Guillaume; Pachl, Fiona; Ruprecht, Benjamin; Klaeger, Susan; Heinzlmeir, Stephanie; Helm, Dominic; Qiao, Huichao; Ku, Xin; Wilhelm, Mathias; Kuehne, Thomas; Wu, Zhixiang; Dittmann, Antje; Hopf, Carsten; Kramer, Karl; Kuster, Bernhard
Title:
Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling
Abstract:
Solid supported probes have proven to be an efficient tool for chemical proteomics. The kinobeads technology features kinase inhibitors covalently attached to Sepharose for affinity enrichment of kinomes from cell or tissue lysates. This technology, combined with quantitative mass spectrometry, is of particular interest for the profiling of kinase inhibitors. It often leads to the identification of new targets for medicinal chemistry campaigns where it allows a two-in-one binding and selectivity...    »
Journal title:
Journal of Proteome Research
Year:
2015
Journal volume:
14
Journal issue:
3
Pages contribution:
1574-1586
Publisher:
American Chemical Society (ACS)
E-ISSN:
1535-38931535-3907
Date of publication:
20.02.2015
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