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Document type:
Zeitschriftenaufsatz 
Author(s):
Helm, Dominic; Vissers, Johannes P.C.; Hughes, Christopher J.; Hahne, Hannes; Ruprecht, Benjamin; Pachl, Fiona; Grzyb, Arkadiusz; Richardson, Keith; Wildgoose, Jason; Maier, Stefan K.; Marx, Harald; Wilhelm, Mathias; Becher, Isabelle; Lemeer, Simone; Bantscheff, Marcus; Langridge, James I.; Kuster, Bernhard 
Title:
Ion Mobility Tandem Mass Spectrometry Enhances Performance of Bottom-up Proteomics 
Abstract:
One of the limiting factors in determining the sensitivity of tandem mass spectrometry using hybrid quadrupole orthogonal acceleration time-of-flight instruments is the duty cycle of the orthogonal ion injection system. As a consequence, only a fraction of the generated fragment ion beam is collected by the time-of-flight analyzer. Here we describe a method utilizing postfragmentation ion mobility spectrometry of peptide fragment ions in conjunction with mobility time synchronized orthogonal ion...    »
 
Journal title:
Molecular & Cellular Proteomics 
Year:
2014 
Journal volume:
13 
Journal issue:
12 
Pages contribution:
3709-3715 
Publisher:
Elsevier BV 
E-ISSN:
1535-9476 
Date of publication:
01.12.2014