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- Document type:
- Journal Article
- Author(s):
- Tachibana, Tomoyoshi; Kasajima, Atsuko; Aoki, Takeshi; Tabata, Tomoaki; McNamara, Keely; Yazdani, Samaneh; Satoko, Sato; Fujishima, Fumiyoshi; Motoi, Fuyuhiko; Unno, Michiaki; Sasano, Hironobu
- Title:
- Progesteron receptor expression in insulin producing cells of neuroendocrine neoplasms.
- Abstract:
- Progesterone receptor (PgR) inhibits cell proliferation in pancreatic neuroendocrine neoplasms (PanNEN). In non-neoplastic pancreas, loss of PgR induces β-cell proliferation and insulin production. However, detailed association between PgR and insulin producing PanNENs is poorly understood. Insulin, proinsulin, and PgR were immunolocalized in 82 PanNENs (54 non-functioning PanNENs: NF-PanNENs and 28 insulinomas). The status of immunoreactivity was compared to the clinicopathological factors of the patients. Immunoreactivity was also confirmed by employing the double-immunohistochemistry. These results were also compared with those in non-neoplastic Langerhans islets. PgR immunoreactivity was significantly higher in insulinomas than that in NF-PanNENs (p < 0.001). Insulin and proinsulin immunoreactivity was also detected in 20 (37 %) of (single cell) insulin positive NFs (Inspos-NF-PanNEN), in which PgR expression was higher than in insulin negative NF-PanNENs (Insneg-NF-PanNEN, p = 0.03). The ratio of PgR-insulin double positive cells to overall insulin positive cells, as well as PgR-proinsulin double positive cells to proinsulin positive cells, was detected to the same degree in insulinoma (PgR-insulin 70 %, PgR-proinsulin 66 %), Inspos-NF-PanNENs (PgR-insulin 65 %, PgR-proinsulin 68 %) and normal islet (PgR-insulin 80 %, PgR-proinsulin 72 %). PgR and insulin expressing cells colocalize in tumor cells of the PanNENs regardless of the hormone-related symptoms of the patients. Inhibitory effect of PgR on tumor cells might be associated with the favourable clinical outcome of insulinoma patients.
- Journal title abbreviation:
- J Steroid Biochem Mol Biol
- Year:
- 2020
- Journal volume:
- 201
- Fulltext / DOI:
- doi:10.1016/j.jsbmb.2020.105694
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/32437964
- Print-ISSN:
- 0960-0760
- TUM Institution:
- Institut für Allgemeine Pathologie und Pathologische Anatomie
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