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- Original title:
- Molekulare Charakterisierung der neuroprotektiven Wirkung transmembraner Proteine der TM9-Superfamilie und der TMEFF-Proteine
- Translated title:
- Molecular characterization of neuroprotective effects of transmembrane proteins of the TM9 superfamily 1 and the TMEFF proteins
- Author:
- Wiegand, Anne Katharina Gisela
- Year:
- 2012
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Medizin
- Advisor:
- Schlegel, Jürgen (Prof. Dr.)
- Referee:
- Schlegel, Jürgen (Prof. Dr.); Korn, Thomas (Prof. Dr.)
- Language:
- de
- Subject group:
- MED Medizin
- Keywords:
- TM9SF1, TMEFF1, Neuroprotektion, Hirntumore, Tumorsuppression, relative Expressionsanalyse
- Translated keywords:
- TM9SF1, TMEFF1, neuroprotection, brain tumors, tumor suppression, relative expression analysis
- Abstract:
- Im Rahmen dieser Dissertation sollte die neuroprotektive Wirkung der transmembranen Proteine TM9SF1 und TMEFF1 untersucht werden. Es wurden relative Expressionsanalysen der beiden Proteine an SHSY5Y-Zellen und humanen Gewebeproben im Vergleich zu house-keeping-Genen sowie Klonierungsversuche von TM9SF1 durchgeführt. Im Ergebnis wurden die neuroprotektiven, antiapoptotischen und wachstumsregulierenden Eigenschaften von TM9SF1 und TMEFF1 bestätigt.
- Translated abstract:
- The experiments within the framework of this dissertation were done to investigate the neuroprotective effects of transmembrane proteins like TM9SF1 and TMEFF1. Experiments with relative expression analysis of both genes were executed using SHSY5Y cells and human tissue samples in comparision to house-keeping genes as well as cloning experiments of TM9SF1. The experiments confirmed the postulated neuroprotective, anti-apoptotic and growth regulating qualities of TM9SF1 and TMEFF1.
- WWW:
- https://mediatum.ub.tum.de/?id=982686
- Date of submission:
- 14.07.0010
- Oral examination:
- 22.11.2012
- File size:
- 1598568 bytes
- Pages:
- 77
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20121122-982686-0-5
- Last change:
- 10.05.2013
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