High-molecular weight adiponectin is independently associated with the extent of coronary artery disease in men.

von Eynatten, M; Humpert, PM; Bluemm, A; Lepper, PM; Hamann, A; Allolio, B; Nawroth, PP; Bierhaus, A; Dugi, KA

doi:10.1016/j.atherosclerosis.2007.10.002

journal article

Document type:: Journal Article; Article
Author(s):: von Eynatten, M; Humpert, PM; Bluemm, A; Lepper, PM; Hamann, A; Allolio, B; Nawroth, PP; Bierhaus, A; Dugi, KA
Title:: High-molecular weight adiponectin is independently associated with the extent of coronary artery disease in men.
Abstract:: OBJECTIVE: Adiponectin has anti-atherogenic properties and low circulating adiponectin has been linked to coronary atherosclerosis. Yet, there is considerable evidence that the high-molecular weight (HMW) complex of adiponectin is the major active form of this adipokine. We therefore investigated whether HMW adiponectin is associated with the extent of coronary artery disease (CAD) in men. RESEARCH DESIGN AND METHODS: Associations among CAD, HMW adiponectin and the HMW/total-adiponectin ratio were assessed in 240 male patients undergoing elective coronary angiography. Total adiponectin and HMW adiponectin was measured by enzyme-linked immunosorbent assay and serum levels were correlated with defined coronary scores and established cardiovascular risk factors. RESULTS: We found significant inverse correlations between angiographic scores and HMW adiponectin [Extent Score (ES): r=-0.39; Gensini Score (GS): r=-0.35; and Severity Score (SS): r=-0.40, all P<0.001], and the HMW/total-adiponectin ratio (ES: r=-0.49; GS: r=-0.46; SS: r=-0.46; all P<0.001). Multivariable regression analyses revealed that HMW adiponectin and the HMW/total-adiponectin ratio were significantly associated with the extent of CAD (both P<0.001). ROC analyses demonstrated that the predictive value of HMW adiponectin and the HMW/total-adiponectin ratio for the extent of coronary atherosclerosis significantly exceeded that of total adiponectin (P<0.001, P=0.010, respectively). CONCLUSIONS: HMW adiponectin and the HMW/total-adiponectin ratio inversely correlate with the extent of CAD. HMW adiponectin in particular seems to be a better marker for CAD extent than total adiponectin.
Journal title abbreviation:: Atherosclerosis
Year:: 2008
Journal volume:: 199
Journal issue:: 1
Pages contribution:: 123-8
Language:: eng
Fulltext / DOI:: doi:10.1016/j.atherosclerosis.2007.10.002
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/18021784
Print-ISSN:: 0021-9150
TUM Institution:: Fachgebiet Nephrologie (Prof. Heemann)
BibTeX

Occurrences:

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid)Abteilung für Nephrologie (Prof. Heemann)Professur für Nephrologie (Prof. Heemann)2008