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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Knör, S; Khrenov, A; Laufer, B; Benhida, A; Grailly, SC; Schwaab, R; Oldenburg, J; Beaufort, N; Magdolen, V; Saint-Remy, JM; Saenko, EL; Hauser, CA; Kessler, H 
Title:
Efficient factor VIII affinity purification using a small synthetic ligand. 
Abstract:
BACKGROUND: Hemophilia A is currently treated by infusions of the coagulation factor (F) VIII, of which production and purification remain a challenging task. Current purification procedures using immunoaffinity chromatography are cumbersome, expensive, and suffer from the instability of the applied antibody ligands, which elute along with the product and contaminate it. Recently, FVIII was purified using octapeptide ligands, but their use is limited due to the low resistance to proteases. OBJEC...    »
 
Journal title abbreviation:
J Thromb Haemost 
Year:
2008 
Journal volume:
Journal issue:
Pages contribution:
470-7 
Language:
eng 
Print-ISSN:
1538-7933 
TUM Institution:
Frauenklinik und Poliklinik