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Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
De Filippo, K; Henderson, RB; Laschinger, M; Hogg, N
Title:
Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways.
Abstract:
Neutrophils are the first immune cells to migrate into infected tissue sites. Therefore an important step in the initiation of an immune response is the synthesis of the neutrophil-recruiting chemokines. In this in vivo study in mice, we show that resident tissue macrophages are the source of the major neutrophil chemoattractants, KC and MIP-2. Synthesis of these chemokines is rapidly regulated at the transcriptional level by signaling through TLR2, TLR3, and TLR4 that have diverse specificities...    »
Journal title abbreviation:
J Immunol
Year:
2008
Journal volume:
180
Journal issue:
6
Pages contribution:
4308-15
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18322244
Print-ISSN:
0022-1767
TUM Institution:
Chirurgische Klinik und Poliklinik
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