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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Traeger, T; Kessler, W; Assfalg, V; Cziupka, K; Koerner, P; Dassow, C; Breitbach, K; Mikulcak, M; Steinmetz, I; Pfeffer, K; Heidecke, CD; Maier, S
Title:
Detrimental role of CC chemokine receptor 4 in murine polymicrobial sepsis.
Abstract:
CC chemokine receptor 4 (CCR4) and its two ligands, CCL17 and CCL22, are critically involved in different immune processes. In models of lipopolysaccharide-induced shock, CCR4-deficient (CCR4(-/-)) mice showed improved survival rates associated with attenuated proinflammatory cytokine release. Using CCR4(-/-) mice with a C57BL/6 background, this study describes for the first time the role of CCR4 in a murine model of polymicrobial abdominal sepsis, the colon ascendens stent peritonitis (CASP). C...     »
Journal title abbreviation:
Infect Immun
Year:
2008
Journal volume:
76
Journal issue:
11
Pages contribution:
5285-93
Language:
eng
Fulltext / DOI:
doi:10.1128/IAI.00310-08
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18765730
Print-ISSN:
0019-9567
TUM Institution:
Chirurgische Klinik und Poliklinik
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