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- Document type:
- Journal Article; Article
- Author(s):
- Nieder, C; Astner, ST; Andratschke, NH; Adam, M
- Title:
- Disease presentation and outcome in very young patients with brain metastases from breast cancer.
- Abstract:
- AIMS AND BACKGROUND: Little information is available on disease presentation and treatment outcome in very young patients with brain metastases from breast cancer. Therefore, we evaluated our results in this group. METHODS: In our database, 7/74 breast cancer patients treated for brain metastases were < 40 years old. All received whole-brain radiation therapy plus individual local or systemic measures. RESULTS: In patients with information available, tumors were poorly differentiated and metastatic to the axillary lymph nodes at primary diagnosis. All patients had extracranial metastases. Two died from their brain disease within 5 months. Five patients died from extracranial progression after 3-84 months (2 long-term survivors beyond 2 years, characterized by single brain lesions and high performance status). CONCLUSIONS: Very young patients did not achieve a better outcome than intermediate age groups. Whole-brain radiation therapy plus surgery or radiosurgery provided durable CNS control in most of the patients. Improved systemic therapy appears to represent the key to a better outcome.
- Journal title abbreviation:
- Tumori
- Year:
- 2008
- Journal volume:
- 94
- Journal issue:
- 5
- Pages contribution:
- 691-3
- Language:
- eng
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/19112942
- Print-ISSN:
- 0300-8916
- TUM Institution:
- Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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