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- Dokumenttyp:
- Zeitschriftenaufsatz
- Autor(en):
- Linke, K., Periasamy, N., Ehrmann, M., Winter, R. and Vogel, R. F.
- Titel:
- Influence of high pressure on the dimerization of ToxR, a protein involved in bacterial signal transduction.
- Abstract:
- High hydrostatic pressure (HHP) is suggested to influence the structure and function of membranes and/or integrated proteins. We demonstrate for the first time HHP-induced dimer dissociation of membrane proteins in vivo with Vibrio cholerae ToxR variants in Escherichia coli reporter strains carrying ctx:lacZ fusions. Dimerization ceased at 20 to 50 MPa depending on the nature of the transmembrane segments rather than on changes in the ToxR lipid bilayer environment.
- Stichworte:
- toxR
- Zeitschriftentitel:
- Appl.Environ. Microbiol
- Jahr:
- 2008
- Band / Volume:
- 74
- Heft / Issue:
- 24
- Seitenangaben Beitrag:
- 7821-3
- Sprache:
- en
- Format:
- Text
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