Login
- Original title:
- Phänotypische Veränderungen von Blut-Monozyten während eines ST-Hebungs-Myokardinfarkts
- Translated title:
- Phenotypical changes in blood-monocytes during ST-elevation myocardial infarction
- Author:
- López Armbruster, Nicolás
- Year:
- 2022
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Medizin
- Advisor:
- Sager, Hendrik (Prof. Dr.)
- Referee:
- Sager, Hendrik (Prof. Dr.); Mägdefessel, Lars (Prof. Dr.)
- Language:
- de
- Subject group:
- MED Medizin
- Keywords:
- Myokardinfarkt, STEMI, Monozyt, CD14
- Translated keywords:
- myocardial infarction, STEMI, monocytes, CD14
- TUM classification:
- MED 410
- Abstract:
- Ein akuter Myokardinfarkt führt im Zuge der systemischen Immunantwort zur Bereitstellung von phänotypisch verschiedenen Blut-Monozyten. Klassische, inflammatorische (CD14-positive) Blut-Monozyten von Patienten mit akutem STEMI zeigen signifikante Genexpressionsänderungen mit zunächst pro-inflammatorischen und später pro-reparativen Veränderungen. Insbesondere die differentielle Expression der Gene CYP19A1, THBS1, CLU, TRPM6, MTUS1, CRIP2, IL1R2, IL1R1, IL1RAP, IL18R1, IL18RAP, IL21R, CX3CR1 deut... »
- Translated abstract:
- Acute myocardial infarction induces the supply of phenotypically different blood-monocytes during the following systemic inflammatory response. Classical, inflammatory (CD14-positive) blood monocytes from patients with acute STEMI show significant changes in gene expression and first pro-inflammatory and later pro-reparative adaptions. Specifically, differential expression of genes CYP19A1, THBS1, CLU, TRPM6, MTUS1, CRIP2, IL1R2, IL1R1, IL1RAP, IL18R1, IL18RAP, IL21R and CX3CR1 indicates their i... »
- WWW:
- https://mediatum.ub.tum.de/?id=1657739
- Date of submission:
- 16.05.2022
- Oral examination:
- 27.10.2022
- File size:
- 7466656 bytes
- Pages:
- 128
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20221027-1657739-1-2
- Last change:
- 18.11.2022
BibTeX