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- Dokumenttyp:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Autor(en):
- Perneczky, R; Diehl-Schmid, J; Pohl, C; Drzezga, A; Kurz, A
- Titel:
- Non-fluent progressive aphasia: cerebral metabolic patterns and brain reserve.
- Abstract:
- Functional imaging studies suggest that brain reserve allows patients with Alzheimer's disease with more years of schooling to cope better with brain damage. No studies exist on patients with non-fluent progressive aphasia (NFPA). We aimed to explore metabolic patterns of patients with NFPA and to provide evidence for brain reserve in NFPA. 11 right-handed patients with NFPA and 16 age-matched controls underwent (18)F-FDG PET imaging. Scans of patients and controls were compared in SPM2. A linear regression analysis with glucose metabolism as dependent variable and years of schooling as the independent variable, adjusted for age, gender, and a total score of the CERAD neuropsychological battery was conducted. The NFPA group showed a hypometabolism of the left hemisphere including the middle frontal, and inferior temporal and angular gyri, and the bilateral caudate nuclei and thalami (p(corr)<0.05). The regression analysis revealed a significant inverse association between education and glucose metabolism in the left inferior temporal, parahippocampal, and supramarginal gyri (p(corr)<0.05). We conclude that brain reserve is also present in NFPA.
- Zeitschriftentitel:
- Brain Res
- Jahr:
- 2007
- Band / Volume:
- 1133
- Heft / Issue:
- 1
- Seitenangaben Beitrag:
- 178-85
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1016/j.brainres.2006.11.054
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/17184752
- Print-ISSN:
- 0006-8993
- TUM Einrichtung:
- Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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