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Document type:
Zeitschriftenaufsatz 
Author(s):
Frey, Stephan; Leskovar, Adriane; Reinstein, Jochen; Buchner, Johannes 
Title:
The ATPase Cycle of the Endoplasmic Chaperone Grp94 
Abstract:
Grp94, the Hsp90 paralog of the endoplasmic reticulum, plays a crucial role in protein secretion. Like cytoplasmic Hsp90, Grp94 is regulated by nucleotide binding to its N-terminal domain. However, the question of whether Grp94 hydrolyzes ATP was controversial. This sets Grp94 apart from other members of the Hsp90 family where a slow but specific turnover of ATP has been unambiguously established. In this study we aimed at analyzing the nucleotide binding properties and the potential ATPase acti...    »
 
Journal title:
J. Biol. Chem. 
Year:
2007 
Journal volume:
282 
Journal issue:
49 
Pages contribution:
35612-35620 
Language:
de 
Fulltext / DOI:
Status:
published (reviewed) 
TUM Institution:
Lehrstuhl für Biotechnologie 
Format:
Text