Pauli, Theresa M.;Julius, Ayse;Costa, Francesco;Eschrig, Sabine;Moosmüller, Judith;Fischer, Lea;Schanzenbach, Christoph;Schmidt, Fabian C.;Ortner, Martin;Langosch, Dieter
Interaction of Substrates with γ-Secretase at the Level of Individual Transmembrane Helices—A Methodological Approach
International Journal of Molecular Sciences
2023
24
18
14396

Ortner, Martin;Guschtschin-Schmidt, Nadja;Stelzer, Walter;Muhle-Goll, Claudia;Langosch, Dieter
Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by γ-Secretase
Journal of Molecular Biology
2023
435
18
168218

Schmidt, FabianC.;Fitz, Katja;Feilen, LukasP.;Okochi, Masayasu;Steiner, Harald;Langosch, Dieter
Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin
Journal of Biological Chemistry
2023
104626

Güner, Gökhan;Aßfalg, Marlene;Zhao, Kai;Dreyer, Tobias;Lahiri, Shibojyoti;Lo, Yun;Slivinschi, Bianca Ionela;Imhof, Axel;Jocher, Georg;Strohm, Laura;Behrends, Christian;Langosch, Dieter;Bronger, Holger;Nimsky, Christopher;Bartsch, Jörg W;Riddell, Stanley R;Steiner, Harald;Lichtenthaler, Stefan F
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity
EMBO Molecular Medicine
2022
14
10

Werner, Nadine T.;Högel, Philipp;Güner, Gökhan;Stelzer, Walter;Wozny, Manfred;Aßfalg, Marlene;Lichtenthaler, Stefan F.;Steiner, Harald;Langosch, Dieter
Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase
Communications Biology
2023
6
1

Ortner, Martin;Stelzer, Walter;Schmidt, Fabian;Guetlich, Markus;Langosch, Dieter
An advanced yeast model to investigate the interplay between structure and function of human gamma-secretase and its substrates
Biophysical Journal
2022
121
3
342a

Papadopoulou, Alkmini A.;Stelzer, Walter;Silber, Mara;Schlosser, Christine;Spitz, Charlotte;Haug-Kröper, Martina;Straub, Tobias;Müller, Stephan A.;Lichtenthaler, Stefan F.;Muhle-Goll, Claudia;Langosch, Dieter;Fluhrer, Regina
Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage
Scientific Reports
2022
12
1

Heckmeier, Philipp J.;Langosch, Dieter
Site-Specific Fragmentation of Green Fluorescent Protein Induced by Blue Light
Biochemistry
2021
60
32
2457-2462

Spitz, Charlotte;Schlosser, Christine;Guschtschin-Schmidt, Nadja;Stelzer, Walter;Menig, Simon;Götz, Alexander;Haug-Kröper, Martina;Scharnagl, Christina;Langosch, Dieter;Muhle-Goll, Claudia;Fluhrer, Regina
Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix
iScience
2020
23
12
101775

Xiao, Yao;Zeng, Bo;Berner, Nicola;Frishman, Dmitrij;Langosch, Dieter;George Teese, Mark
Experimental determination and data-driven prediction of homotypic transmembrane domain interfaces
Computational and Structural Biotechnology Journal
2020
18
3230-3242