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Document type:
Zeitschriftenaufsatz 
Author(s):
Daryadel, Arezoo; Ruiz, Pedro A.; Gehring, Nicole; Stojanovic, Dragana; Ugrica, Marko; Bettoni, Carla; Sabrautzki, Sibylle; Pastor-Arroyo, Eva-Maria; Frey-Wagner, Isabelle; Lorenz-Depiereux, Bettina; Strom, Tim M.; de Angelis, Martin Hrabě; Rogler, Gerhard; Wagner, Carsten A.; Rubio-Aliaga, Isabel 
Title:
Systemic Jak1 activation provokes hepatic inflammation and imbalanced FGF23 production and cleavage 
Abstract:
Abstract Fibroblast growth factor 23 (FGF23) is a main regulator of mineral homeostasis. Low and high circulating FGF23 levels are associated with bone, renal, cardiovascular diseases, and increased mortality. Understanding the factors and signaling pathways affecting FGF23 levels is crucial for the management of these diseases and their complications. Here, we show that activation of the Jak1/Stat3 signaling pathway leads to inflammation in liver and to an increase in hepatic FGF23 synthesis, a...    »
 
Keywords:
FGF23, Jak/Stat signaling, inflammation, calcitriol, PTH 
Journal title:
The FASEB Journal 
Year:
2021 
Journal volume:
35 
Journal issue: