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Document type:
journal article 
Author(s):
Keskin, Aylin D; Keku?, Maja; Adelsberger, Helmuth; Neumann, Ulf; Shimshek, Derya R; Song, Beomjong; Zott, Benedikt; Peng, Tingying; Förstl, Hans; Staufenbiel, Matthias; Nelken, Israel; Sakmann, Bert; Konnerth, Arthur; Busche, Marc Aurel 
Title:
BACE inhibition-dependent repair of Alzheimer's pathophysiology. 
Abstract:
Amyloid-? (A?) is thought to play an essential pathogenic role in Alzheimer´s disease (AD). A key enzyme involved in the generation of A? is the ?-secretase BACE, for which powerful inhibitors have been developed and are currently in use in human clinical trials. However, although BACE inhibition can reduce cerebral A? levels, whether it also can ameliorate neural circuit and memory impairments remains unclear. Using histochemistry, in vivo Ca imaging, and behavioral analyses in a mouse model of...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2017 
Journal volume:
114 
Journal issue:
32 
Pages contribution:
8631-8636 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
Institut für Neurowissenschaften; Klinik und Poliklinik für Psychiatrie und Psychotherapie