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Document type:
journal article 
Author(s):
Wong, W Wei-Lynn; Vince, James E; Lalaoui, Najoua; Lawlor, Kate E; Chau, Diep; Bankovacki, Aleksandra; Anderton, Holly; Metcalf, Donald; O'Reilly, Lorraine; Jost, Philipp J; Murphy, James M; Alexander, Warren S; Strasser, Andreas; Vaux, David L; Silke, John 
Title:
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. 
Abstract:
Loss of inhibitor of apoptosis proteins (IAPs), particularly cIAP1, can promote production of tumor necrosis factor (TNF) and sensitize cancer cell lines to TNF-induced necroptosis by promoting formation of a death-inducing signaling complex containing receptor-interacting serine/threonine-protein kinase (RIPK) 1 and 3. To define the role of IAPs in myelopoiesis, we generated a mouse with cIAP1, cIAP2, and XIAP deleted in the myeloid lineage. Loss of cIAPs and XIAP in the myeloid lineage caused...    »
 
Journal title abbreviation:
Blood 
Year:
2014 
Journal volume:
123 
Journal issue:
16 
Pages contribution:
2562-72 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Klinik und Poliklinik für Innere Medizin III