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Document type:
journal article 
Author(s):
Schober, Kilian; Buchholz, Veit R; Busch, Dirk H 
Title:
TCR repertoire evolution during maintenance of CMV-specific T-cell populations. 
Abstract:
During infections and cancer, the composition of the T-cell receptor (TCR) repertoire of antigen-specific CD8 T cells changes over time. TCR avidity is thought to be a major driver of this process, thereby interacting with several additional regulators of T-cell responses to form a composite immune response architecture. Infections with latent viruses, such as cytomegalovirus (CMV), can lead to large T-cell responses characterized by an oligoclonal TCR repertoire. Here, we review the current sta...    »
 
Journal title abbreviation:
Immunol Rev 
Year:
2018 
Journal volume:
283 
Journal issue:
Pages contribution:
113-128 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0105-2896 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene