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Document type:
journal article 
Author(s):
von der Wellen, Jens; Winterhalter, Peter; Siegert, Markus; Eyer, Florian; Thiermann, Horst; John, Harald 
Title:
A toolbox for microbore liquid chromatography tandem-high-resolution mass spectrometry analysis of albumin-adducts as novel biomarkers of organophosphorus pesticide poisoning. 
Abstract:
Exposure to toxic organophosphorus pesticides (OPP) represents a serious problem in the public healthcare sector and might be forced in terroristic attacks. Therefore, reliable verification procedures for OPP-intoxications are required for forensic, toxicological and clinical reasons. We developed and optimized a toolbox of methods to detect adducts of human serum albumin (HSA) with OPP considered as long-term biomarkers. Human serum was incubated with diethyl-oxono and diethyl-thiono pesticides...    »
 
Journal title abbreviation:
Toxicol Lett 
Year:
2018 
Journal volume:
292 
Pages contribution:
46-54 
Language:
eng 
Print-ISSN:
0378-4274 
TUM Institution:
Abteilung für Klinische Toxikologie