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- Original title:
- Imaging Flow Cytometry als Werkzeug zur Untersuchung FoxP3-positiver regulatorischer B-Zellen
- Translated title:
- Imaging flow cytometry as a tool for FoxP3-positive regulatory B cell analysis
- Author:
- Kindsmüller, Antonia Lina
- Year:
- 2024
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Medicine and Health
- Advisor:
- Schmidt-Weber, Carsten (Prof. Dr.)
- Referee:
- Schmidt-Weber, Carsten (Prof. Dr.); Chaker, Adam (Priv.-Doz. Dr.)
- Language:
- de
- Subject group:
- MED Medizin
- Keywords:
- Breg, regulatorische B-Zellen, Allergie, AIT, FoxP3, IL-10, IFC, Imaging Flow Cytometry
- Translated keywords:
- Breg, regulatory B cells, allergy, AIT, FoxP3, IL-10, IFC, Imaging Flow Cytometry
- TUM classification:
- MED 490
- Abstract:
- Die Imaging Flow Cytometry zeigte sich als valide Methode zur bildlichen Darstellung und quantitativen Untersuchung des seltenen Zelltyps der Interleukin 10- (IL-10) und FoxP3-positiven regulatorischen B-Zellen (Bregs). Die Daten weisen darauf hin, dass hier die Steuerung der IL-10-Sekretion nicht über FoxP3 erfolgt sondern FoxP3 einen anderen anti-inflammatorischen Prozess steuert und Bregs zur Homöostase des Immunsystems beitragen.
- Translated abstract:
- Imaging Flow Cytometry can successfully be applied for rare event detection and imaging for Interleukin 10 (IL-10) and FoxP3-positive regulatory B cells (Bregs). FoxP3 was only found in a small subgroup of IL-10+Bregs, indicating that IL-10 might not be the only anti-inflammatory mechanism for FoxP3+Bregs and IL-10 secretion might not be regulated only by FoxP3. However, data suggest the overarching role of Breg in homeostasis of the immune system.
- WWW:
- https://mediatum.ub.tum.de/?id=1702095
- Date of submission:
- 20.03.2023
- Oral examination:
- 26.02.2024
- File size:
- 3883263 bytes
- Pages:
- 100
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20240226-1702095-1-2
- Last change:
- 26.06.2024
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