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Original title:
Untersuchungen zur Bildung von Tight Junctions in der humanen Colon-Adenocarcinom-Zellinie HT29
Translated title:
Investigations on formation of tight junctions in the human colon-adenocarcinoma-cell line HT29
Author:
Faff, Ortwin Michael
Year:
1985
Document type:
Dissertation
Faculty/School:
TUM School of Natural Sciences
Advisor:
Bacher, A. (Prof. Dr. Dr.)
Referee:
Bacher, A. (Prof. Dr. Dr.); Honegger, H.-W. (Prof. Dr.)
Language:
de
Subject group:
BIO Biowissenschaften
Keywords:
tight junctions, Induktion, Bildung, Endopeptidase, hypertone, chaotrope Salze, Protease Inhibitoren, PMSF
Translated keywords:
tight junctions, assembly, induction, endopeptidases, hypertonic, chaotropic salts, protease inhibitors, PMSF
TUM classification:
BIO 000
Abstract:
HT29 Zellen bilden in Zellkultur "tight junctions" (TJ) nach Behandlung mit Endopeptidasen. Dieser Prozess erfolgt innerhalb 3-5 Minuten, erfordert Protease Aktivität und ist temperatur-abhängig, was auf die Interaktion zellulärer Proteine und Lipide hinweist. Alternativ entstehen TJ durch Behandlung von HT29 Zellen mit hypertonen chaotropen Salzen z. B. (NH4)2SO4. Dieser Prozess wird durch Serin-Protease-Inhibitoren (PMSF) gehemmt, was die Beteiligung zellulärer Proteasen an der TJ Bildung aufz...     »
Translated abstract:
Formation of tight junctions (TJ) can be induced in cultured cells HT29 by treatment with endopeptidases. This process occurs within 3-5 minutes, requires protease activity and is temperature dependent, indicating interaction of cellular proteins and lipids. Alternatively TJ formation can be induced by hypertonic chaotropic salts e.g. (NH4)2SO4. This process is inhibited by serine protease inhibitors (e.g. PMSF) indicating, that cellular proteases are involved in TJ formation.
WWW:
https://mediatum.ub.tum.de/?id=1730629
Date of submission:
22.07.1985
Oral examination:
14.08.1985
File size:
144170792 bytes
Pages:
135
Urn (citeable URL):
https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-19850814-1730629-0-0
Last change:
02.01.2024
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