Tumour budding-based grading as independent prognostic biomarker in HPV-positive and HPV-negative head and neck cancer.

Stögbauer, Fabian; Beck, Susanne; Ourailidis, Iordanis; Hess, Jochen; Poremba, Christopher; Lauterbach, Maren; Wollenberg, Barbara; Buchberger, Anna Maria Stefanie; Jesinghaus, Moritz; Schirmacher, Peter; Stenzinger, Albrecht; Weichert, Wilko; Boxberg, Melanie; Budczies, Jan

doi:10.1038/s41416-023-02240-y

Benutzer: Gast

2023

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Titel:: Tumour budding-based grading as independent prognostic biomarker in HPV-positive and HPV-negative head and neck cancer.
Dokumenttyp:: Journal Article; Research Support, Non-U.S. Gov't
Autor(en):: Stögbauer, Fabian; Beck, Susanne; Ourailidis, Iordanis; Hess, Jochen; Poremba, Christopher; Lauterbach, Maren; Wollenberg, Barbara; Buchberger, Anna Maria Stefanie; Jesinghaus, Moritz; Schirmacher, Peter; Stenzinger, Albrecht; Weichert, Wilko; Boxberg, Melanie; Budczies, Jan
Abstract:: BACKGROUND: The prognostic significance of tumour budding (TB) and minimal cell nest size (MCNS) was shown in human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC). However, the optimisation of cutpoints, the prognostic impact in HPV-positive HNSCC, and the comparison with other histopathological grading systems are insufficiently investigated. METHODS: TB and MCNS were analysed digitally in 1 and 10 high-power fields (HPF) of 331 HPV-positive and HPV-negative cases from TCGA. Optimising the cutpoints a new cellular dissociation grading (CDG) system was defined and compared to the WHO grading and the Brandwein-Gensler (BG) risk model. RESULTS: The two-tiered CDG system based solely on TB yielded optimal prognostic stratification with shortened overall survival for CDG-high cases. Optimal cut-offs were two buds (1 HPF) and six buds (10 HPF), respectively. Analysing MCNS did not add prognostic significance to quantifying TB. CDG was a significant prognostic marker in HPV-negative and HPV-positive tumours and prognostically superior to the WHO and BG systems. High CDG was associated with clinically occult lymph-node metastases. CONCLUSIONS: The most comprehensive study of TB in HNSCC so far confirmed its prognostic impact in HPV-negative tumours and for the first time in HPV-positive tumours. Further studies are warranted to evaluate its applicability for therapy guidance in HNSCC. «
BACKGROUND: The prognostic significance of tumour budding (TB) and minimal cell nest size (MCNS) was shown in human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC). However, the optimisation of cutpoints, the prognostic impact in HPV-positive HNSCC, and the comparison with other histopathological grading systems are insufficiently investigated. METHODS: TB and MCNS were analysed digitally in 1 and 10 high-power fields (HPF) of 331 HPV-positive and HPV-negative cases... »
Zeitschriftentitel:: Br J Cancer
Jahr:: 2023
Band / Volume:: 128
Heft / Issue:: 12
Seitenangaben Beitrag:: 2295-2306
Volltext / DOI:: doi:10.1038/s41416-023-02240-y
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/37045906
Print-ISSN:: 0007-0920
TUM Einrichtung:: Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)
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mediaTUM Gesamtbestand Hochschulbibliographie 2023 Schools und Fakultäten Medizin Institut für Allgemeine Pathologie und Pathologische Anatomie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Preclinical Medicine Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.)2023