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Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Dudek, Michael; Lohr, Kerstin; Donakonda, Sainitin; Baumann, Tobias; Lüdemann, Max; Hegenbarth, Silke; Dübbel, Lena; Eberhagen, Carola; Michailidou, Savvoula; Yassin, Abdallah; Prinz, Marco; Popper, Bastian; Rose-John, Stefan; Zischka, Hans; Knolle, Percy A
Title:
IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.
Abstract:
Liver sinusoidal endothelial cells (LSECs) are liver-resident antigen (cross)-presenting cells that generate memory CD8 T cells, but metabolic properties of LSECs and LSEC-primed CD8 T cells remain understudied. Here, we report that high-level mitochondrial respiration and constitutive low-level glycolysis support LSEC scavenger and sentinel functions. LSECs fail to increase glycolysis and co-stimulation after TLR4 activation, indicating absence of metabolic and functional maturation compared wi...     »
Journal title abbreviation:
Cell Rep
Year:
2022
Journal volume:
38
Journal issue:
7
Fulltext / DOI:
doi:10.1016/j.celrep.2022.110389
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35172161
Print-ISSN:
2211-1247
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Institut für Toxikologie und Umwelthygiene (Prof. Göttlicher); Roman Herzog Comprehensive Cancer Center
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