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Document type:
Article; Early Access; Journal Article
Author(s):
Giordano, Luca; Aneja, Manish K; Sommer, Natascha; Alebrahimdehkordi, Nasim; Seraji, Alireza; Weissmann, Norbert; Rudolph, Carsten; Plank, Christian; Jacobs, Howard T; Szibor, Marten
Title:
Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active.
Abstract:
Plants and other organisms, but not insects or vertebrates, express the auxiliary respiratory enzyme alternative oxidase (AOX) that bypasses mitochondrial respiratory complexes III and/or IV when impaired. Persistent expression of AOX from Ciona intestinalis in mammalian models has previously been shown to be effective in alleviating some metabolic stresses produced by respiratory chain inhibition while exacerbating others. This implies that chronic AOX expression may modify or disrupt metabolic...    »
Journal title abbreviation:
Gene Ther
Year:
2021
Print-ISSN:
0969-7128
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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