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Document type:
Article; Early Access; Journal Article 
Author(s):
Giordano, Luca; Aneja, Manish K; Sommer, Natascha; Alebrahimdehkordi, Nasim; Seraji, Alireza; Weissmann, Norbert; Rudolph, Carsten; Plank, Christian; Jacobs, Howard T; Szibor, Marten 
Title:
Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. 
Abstract:
Plants and other organisms, but not insects or vertebrates, express the auxiliary respiratory enzyme alternative oxidase (AOX) that bypasses mitochondrial respiratory complexes III and/or IV when impaired. Persistent expression of AOX from Ciona intestinalis in mammalian models has previously been shown to be effective in alleviating some metabolic stresses produced by respiratory chain inhibition while exacerbating others. This implies that chronic AOX expression may modify or disrupt metabolic...    »
 
Journal title abbreviation:
Gene Ther 
Year:
2021 
Print-ISSN:
0969-7128 
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung