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Document type:
Review; Journal Article; Research Support, Non-U.S. Gov't; Review 
Author(s):
Tilg, Herbert; Adolph, Timon E; Dudek, Michael; Knolle, Percy 
Title:
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity. 
Abstract:
Non-alcoholic fatty liver disease (NAFLD) has emerged pandemically across the globe and particularly affects patients with obesity and type 2 diabetes. NAFLD is a complex systemic disease that is characterised by hepatic lipid accumulation, lipotoxicity, insulin resistance, gut dysbiosis and inflammation. In this review, we discuss how metabolic dysregulation, the gut microbiome, innate and adaptive immunity and their interplay contribute to NAFLD pathology. Lipotoxicity has been shown to instig...    »
 
Journal title abbreviation:
Nat Metab 
Year:
2021 
Journal volume:
Journal issue:
12 
Pages contribution:
1596-1607 
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Roman Herzog Comprehensive Cancer Center