User: Guest  Login
Document type:
Article; Journal Article 
Author(s):
Mohan, Vishnu; Gaffney, Jean P; Solomonov, Inna; Levin, Maxim; Klepfish, Mordehay; Akbareian, Sophia; Grünwald, Barbara; Dym, Orly; Eisenstein, Miriam; Yu, Kenneth H; Kelsen, David P; Krüger, Achim; Edwards, Dylan R; Sagi, Irit 
Title:
Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill. 
Abstract:
Matrix metalloproteases (MMPs) undergo post-translational modifications including pro-domain shedding. The activated forms of these enzymes are effective drug targets, but generating potent biological inhibitors against them remains challenging. We report the generation of anti-MMP-7 inhibitory monoclonal antibody (GSM-192), using an alternating immunization strategy with an active site mimicry antigen and the activated enzyme. Our protocol yielded highly selective anti-MMP-7 monoclonal antibody...    »
 
Journal title abbreviation:
Cancers (Basel) 
Year:
2021 
Journal volume:
13 
Journal issue:
Fulltext / DOI:
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung