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Document type:
Article; Journal Article 
Mohan, Vishnu; Gaffney, Jean P; Solomonov, Inna; Levin, Maxim; Klepfish, Mordehay; Akbareian, Sophia; Grünwald, Barbara; Dym, Orly; Eisenstein, Miriam; Yu, Kenneth H; Kelsen, David P; Krüger, Achim; Edwards, Dylan R; Sagi, Irit 
Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill. 
Matrix metalloproteases (MMPs) undergo post-translational modifications including pro-domain shedding. The activated forms of these enzymes are effective drug targets, but generating potent biological inhibitors against them remains challenging. We report the generation of anti-MMP-7 inhibitory monoclonal antibody (GSM-192), using an alternating immunization strategy with an active site mimicry antigen and the activated enzyme. Our protocol yielded highly selective anti-MMP-7 monoclonal antibody...    »
Journal title abbreviation:
Cancers (Basel) 
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TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung