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Document type:
Meeting Abstract; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Dudek, Michael; Pfister, Dominik; Donakonda, Sainitin; Filpe, Pamela; Schneider, Annika; Laschinger, Melanie; Hartmann, Daniel; Hüser, Norbert; Meiser, Philippa; Bayerl, Felix; Inverso, Donato; Wigger, Jennifer; Sebode, Marcial; Öllinger, Rupert; Rad, Roland; Hegenbarth, Silke; Anton, Martina; Guillot, Adrien; Bowman, Andrew; Heide, Danijela; Müller, Florian; Ramadori, Pierluigi; Leone, Valentina; Garcia-Caceres, Cristina; Gruber, Tim; Seifert, Gabriel; Kabat, Agnieszka M; Mallm, Jan-Philipp; Re...    »
 
Title:
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH. 
Abstract:
Nonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease related to obesity, and causes liver disease and cancer1,2. The accumulation of metabolites leads to cell stress and inflammation in the liver3, but mechanistic understandings of liver damage in NASH are incomplete. Here, using a preclinical mouse model that displays key features of human NASH (hereafter, NASH mice), we found an indispensable role for T cells in liver immunopathology. We detected the hepatic acc...    »
 
Journal title abbreviation:
Nature 
Year:
2021 
Journal volume:
592 
Journal issue:
7854 
Pages contribution:
444-449 
Print-ISSN:
0028-0836 
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Chirurgie; Professur für Translationale gastroenterologische Onkologie (Prof. Rad); Roman Herzog Comprehensive Cancer Center