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- Dokumenttyp:
- Journal Article
- Autor(en):
- Borde, Tabea; Wu, Mingming; Ruschke, Stefan; Boehm, Christof; Stelter, Jonathan; Weiss, Kilian; Metz, Stephan; Makowski, Marcus Richard; Karampinos, Dimitrios C; Fallenberg, Eva Maria
- Titel:
- Assessing breast density using the chemical-shift encoding-based proton density fat fraction in 3-T MRI.
- Abstract:
- OBJECTIVES: There is a clinical need for a non-ionizing, quantitative assessment of breast density, as one of the strongest independent risk factors for breast cancer. This study aims to establish proton density fat fraction (PDFF) as a quantitative biomarker for fat tissue concentration in breast MRI and correlate mean breast PDFF to mammography. METHODS: In this retrospective study, 193 women were routinely subjected to 3-T MRI using a six-echo chemical shift encoding-based water-fat sequence. Water-fat separation was based on a signal model accounting for a single T2* decay and a pre-calibrated 7-peak fat spectrum resulting in volumetric fat-only, water-only images, PDFF- and T2*-values. After semi-automated breast segmentation, PDFF and T2* values were determined for the entire breast and fibroglandular tissue. The mammographic and MRI-based breast density was classified by visual estimation using the American College of Radiology Breast Imaging Reporting and Data System categories (ACR A-D). RESULTS: The PDFF negatively correlated with mammographic and MRI breast density measurements (Spearman rho: -0.74, p < .001) and revealed a significant distinction between all four ACR categories. Mean T2* of the fibroglandular tissue correlated with increasing ACR categories (Spearman rho: 0.34, p < .001). The PDFF of the fibroglandular tissue showed a correlation with age (Pearson rho: 0.56, p = .03). CONCLUSION: The proposed breast PDFF as an automated tissue fat concentration measurement is comparable with mammographic breast density estimations. Therefore, it is a promising approach to an accurate, user-independent, and non-ionizing breast density assessment that could be easily incorporated into clinical routine breast MRI exams. KEY POINTS: • The proposed PDFF strongly negatively correlates with visually determined mammographic and MRI-based breast density estimations and therefore allows for an accurate, non-ionizing, and user-independent breast density measurement. • In combination with T2*, the PDFF can be used to track structural alterations in the composition of breast tissue for an individualized risk assessment for breast cancer.
- Zeitschriftentitel:
- Eur Radiol
- Jahr:
- 2023
- Band / Volume:
- 33
- Heft / Issue:
- 6
- Seitenangaben Beitrag:
- 3810-3818
- Volltext / DOI:
- doi:10.1007/s00330-022-09341-x
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/36538074
- Print-ISSN:
- 0938-7994
- TUM Einrichtung:
- Institut für Diagnostische und Interventionelle Radiologie
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