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Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. 
Author(s):
Li, Qian; Liu, Xiang; Yang, Jimin; Erlund, Iris; Lernmark, Åke; Hagopian, William; Rewers, Marian; She, Jin-Xiong; Toppari, Jorma; Ziegler, Anette-G; Akolkar, Beena; Krischer, Jeffrey P 
Title:
Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes: The TEDDY Study. 
Abstract:
Children's plasma metabolome, especially lipidome, reflects gene regulation and dietary exposures, heralding the development of islet autoantibodies (IA) and type 1 diabetes (T1D). The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8,676 newborns by screening of HLA-DR-DQ genotypes at six clinical centers in four countries, profiled metabolome, and measured concentrations of ascorbic acid, 25-hydroxyvitamin D [25(OH)D], and erythrocyte membrane fatty acids following b...    »
 
Journal title abbreviation:
Diabetes 
Year:
2021 
Journal volume:
70 
Journal issue:
Pages contribution:
282-292 
Fulltext / DOI:
Print-ISSN:
0012-1797 
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin