User: Guest  Login
Document type:
Zeitschriftenaufsatz 
Author(s):
Kimna, Ceren; Lutz, Theresa Monika; Yan, Hongji; Song, Jian; Crouzier, Thomas; Lieleg, Oliver 
Title:
DNA Strands Trigger the Intracellular Release of Drugs from Mucin-Based Nanocarriers 
Abstract:
Gaining control over the delivery of therapeutics to a specific disease site is still very challenging. However, especially when cytotoxic drugs such as chemotherapeutics are used, the importance of a control mechanism that can differentiate “sick” target cells from the surrounding healthy tissue is pivotal. Here, we designed a nanoparticle-based drug delivery process, which releases an active agent only in the presence of a specific trigger DNA sequence. With this strategy, we are able to initi...    »
 
Keywords:
antibiotics doxorubicin drug delivery nanoparticles DNA nanotechnology 
Dewey Decimal Classification:
500 Naturwissenschaften 
Journal title:
ACS Nano 
Year:
2020 
Journal volume:
15 
Journal issue:
Pages contribution:
2350-2362 
Covered by:
Web of Science 
Reviewed:
ja 
Language:
en 
Fulltext / DOI:
Publisher:
American Chemical Society (ACS) 
E-ISSN:
1936-08511936-086X 
Date of publication:
07.08.2020 
TUM Institution:
Professur für Biomechanik