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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Shinde, Prashant V; Xu, Haifeng C; Maney, Sathish Kumar; Kloetgen, Andreas; Namineni, Sukumar; Zhuang, Yuan; Honke, Nadine; Shaabani, Namir; Bellora, Nicolás; Doerrenberg, Mareike; Trilling, Mirko; Pozdeev, Vitaly I; van Rooijen, Nico; Scheu, Stefanie; Pfeffer, Klaus; Crocker, Paul R; Tanaka, Masato; Duggimpudi, Sujitha; Knolle, Percy; Heikenwälder, Mathias; Ruland, Jürgen; Mak, Tak W; Brenner, Dirk; Pandyra, Aleksandra A; Hoell, Jessica I; Borkhardt, Arndt; Häussinger, Dieter; Lang, Karl S; Lan...     »
Title:
Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection.
Abstract:
Innate immune activation is essential to mount an effective antiviral response and to prime adaptive immunity. Although a crucial role of CD169+ cells during vesicular stomatitis virus (VSV) infections is increasingly recognized, factors regulating CD169+ cells during viral infections remain unclear. Here, we show that tumor necrosis factor is produced by CD11b+ Ly6C+ Ly6G+ cells following infection with VSV. The absence of TNF or TNF receptor 1 (TNFR1) resulted in reduced numbers of CD169+ cell...     »
Journal title abbreviation:
J Virol
Year:
2018
Journal volume:
92
Journal issue:
3
Language:
eng
Fulltext / DOI:
doi:10.1128/JVI.01637-17
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29142134
Print-ISSN:
0022-538X
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Roman Herzog Comprehensive Cancer Center
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