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Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Dietachmayr, Michael; Rathakrishnan, Abirami; Karpiuk, Oleksandra; von Zweydorf, Felix; Engleitner, Thomas; Fernández-Sáiz, Vanesa; Schenk, Petra; Ueffing, Marius; Rad, Roland; Eilers, Martin; Gloeckner, Christian Johannes; Clemm von Hohenberg, Katharina; Bassermann, Florian 
Title:
Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival. 
Abstract:
Regulation of mitosis secures cellular integrity and its failure critically contributes to the development, maintenance, and treatment resistance of cancer. In yeast, the dual phosphatase Cdc14 controls mitotic progression by antagonizing Cdk1-mediated protein phosphorylation. By contrast, specific mitotic functions of the mammalian Cdc14 orthologue CDC14B have remained largely elusive. Here, we find that CDC14B antagonizes CDK1-mediated activating mitotic phosphorylation of the deubiquitinase U...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2020 
Journal volume:
11 
Journal issue:
Print-ISSN:
2041-1723 
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)