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Dokumenttyp:
Journal Article
Autor(en):
Gilles, S; Mariani, V; Bryce, M; Mueller, MJ; Ring, J; Behrendt, H; Jakob, T; Traidl-Hoffmann, C
Titel:
Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immune systems towards a T(H)2-dominated response.
Abstract:
Pollen allergy is characterized by a T(H)2-biased immune response to pollen-derived allergens. However, pollen-exposed epithelia do not encounter pure allergen but rather a plethora of protein and non-protein substances. We demonstrated that pollen liberate lipids with chemical and functional similarities to leukotriens and prostaglandins--the pollen associated lipid mediators (PALMs). To date, two main groups of PALMs have been characterized: The immunostimulatory PALMs activating innate immune...    »
Zeitschriftentitel:
Allergy Asthma Clin Immunol
Jahr:
2009
Band / Volume:
5
Heft / Issue:
1
Seitenangaben Beitrag:
3
Sprache:
eng
Volltext / DOI:
doi:10.1186/1710-1492-5-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19946407
Print-ISSN:
1710-1484
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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