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Dokumenttyp:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article 
Autor(en):
Zhao, Z; Wang, Z; Gu, Y; Feil, R; Hofmann, F; Ma, L 
Titel:
Regulate axon branching by the cyclic GMP pathway via inhibition of glycogen synthase kinase 3 in dorsal root ganglion sensory neurons. 
Abstract:
Cyclic GMP has been proposed to regulate axonal development, but the molecular and cellular mechanisms underlying the formation of axon branches are not well understood. Here, we report the use of rodent embryonic sensory neurons from the dorsal root ganglion (DRG) to demonstrate the role of cGMP signaling in axon branching and to identify the downstream molecular pathway mediating this novel regulation. Pharmacologically, a specific cGMP analog promotes DRG axon branching in culture, and this a...    »
 
Zeitschriftentitel:
J Neurosci 
Jahr:
2009 
Band / Volume:
29 
Heft / Issue:
Seitenangaben Beitrag:
1350-60 
Sprache:
eng 
Print-ISSN:
0270-6474 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie 
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