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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Review; Review
Autor(en):
Vilardaga, JP; Bünemann, M; Feinstein, TN; Lambert, N; Nikolaev, VO; Engelhardt, S; Lohse, MJ; Hoffmann, C
Titel:
GPCR and G proteins: drug efficacy and activation in live cells.
Abstract:
Many biochemical pathways are driven by G protein-coupled receptors, cell surface proteins that convert the binding of extracellular chemical, sensory, and mechanical stimuli into cellular signals. Their interaction with various ligands triggers receptor activation that typically couples to and activates heterotrimeric G proteins, which in turn control the propagation of secondary messenger molecules (e.g. cAMP) involved in critically important physiological processes (e.g. heart beat). Successf...    »
Zeitschriftentitel:
Mol Endocrinol
Jahr:
2009
Band / Volume:
23
Heft / Issue:
5
Seitenangaben Beitrag:
590-9
Sprache:
eng
Volltext / DOI:
doi:10.1210/me.2008-0204
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19196832
Print-ISSN:
0888-8809
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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