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Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Zhao, Z; Wang, Z; Gu, Y; Feil, R; Hofmann, F; Ma, L
Title:
Regulate axon branching by the cyclic GMP pathway via inhibition of glycogen synthase kinase 3 in dorsal root ganglion sensory neurons.
Abstract:
Cyclic GMP has been proposed to regulate axonal development, but the molecular and cellular mechanisms underlying the formation of axon branches are not well understood. Here, we report the use of rodent embryonic sensory neurons from the dorsal root ganglion (DRG) to demonstrate the role of cGMP signaling in axon branching and to identify the downstream molecular pathway mediating this novel regulation. Pharmacologically, a specific cGMP analog promotes DRG axon branching in culture, and this a...    »
Journal title abbreviation:
J Neurosci
Year:
2009
Journal volume:
29
Journal issue:
5
Pages contribution:
1350-60
Language:
eng
Print-ISSN:
0270-6474
TUM Institution:
Institut für Pharmakologie und Toxikologie
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