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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Autor(en):
Sawada, N; Itoh, H; Miyashita, K; Tsujimoto, H; Sone, M; Yamahara, K; Arany, ZP; Hofmann, F; Nakao, K 
Titel:
Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels. 
Abstract:
Vascular fibrosis is a major complication of hypertension and atherosclerosis, yet it is largely untreatable. Natriuretic peptides (NPs) repress fibrogenic activation of vascular smooth muscle cells (VSMCs), but the intracellular mechanism mediating this effect remains undetermined. Here we show that inhibition of RhoA through phosphorylation at Ser188, the site targeted by the NP effector cyclic GMP (cGMP)-dependent protein kinase I (cGK I), is critical to fully exert antifibrotic potential. cG...    »
 
Zeitschriftentitel:
Mol Cell Biol 
Jahr:
2009 
Band / Volume:
29 
Heft / Issue:
22 
Seitenangaben Beitrag:
6018-32 
Sprache:
eng 
Volltext / DOI:
Print-ISSN:
0270-7306 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie