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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Sawada, N; Itoh, H; Miyashita, K; Tsujimoto, H; Sone, M; Yamahara, K; Arany, ZP; Hofmann, F; Nakao, K
Title:
Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels.
Abstract:
Vascular fibrosis is a major complication of hypertension and atherosclerosis, yet it is largely untreatable. Natriuretic peptides (NPs) repress fibrogenic activation of vascular smooth muscle cells (VSMCs), but the intracellular mechanism mediating this effect remains undetermined. Here we show that inhibition of RhoA through phosphorylation at Ser188, the site targeted by the NP effector cyclic GMP (cGMP)-dependent protein kinase I (cGK I), is critical to fully exert antifibrotic potential. cG...    »
Journal title abbreviation:
Mol Cell Biol
Year:
2009
Journal volume:
29
Journal issue:
22
Pages contribution:
6018-32
Language:
eng
Print-ISSN:
0270-7306
TUM Institution:
Institut für Pharmakologie und Toxikologie
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