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Dokumenttyp:
Journal Article
Autor(en):
Frenzel, LP; Abdullah, Z; Kriegeskorte, AK; Dieterich, R; Lange, N; Busch, DH; Krönke, M; Utermöhlen, O; Hescheler, J; Sari?, T
Titel:
Role of natural-killer group 2 member D ligands and intercellular adhesion molecule 1 in natural killer cell-mediated lysis of murine embryonic stem cells and embryonic stem cell-derived cardiomyocytes.
Abstract:
The transplantation of cardiomyocytes derived from embryonic stem (ES) cells into infarcted heart has been shown to improve heart function in animal models. However, immune rejection of transplanted cells may hamper the clinical application of this approach. Natural killer (NK) cells could play an important role in this process in both autologous and allogeneic settings by eliminating cells expressing low levels of major histocompatibility complex (MHC) class I molecules. Here we characterize em...    »
Zeitschriftentitel:
Stem Cells
Jahr:
2009
Band / Volume:
27
Heft / Issue:
2
Seitenangaben Beitrag:
307-16
Sprache:
eng
Volltext / DOI:
doi:10.1634/stemcells.2008-0528
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18988711
Print-ISSN:
1066-5099
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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