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Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Harner, S; Noessner, E; Nadas, K; Leumann-Runge, A; Schiemann, M; Faber, FL; Heinrich, J; Krauss-Etschmann, S
Title:
Cord blood V?24-V?11 natural killer T cells display a Th2-chemokine receptor profile and cytokine responses.
Abstract:
The fetal immune system is characterized by a Th2 bias but it is unclear how the Th2 predominance is established. Natural killer T (NKT) cells are a rare subset of T cells with immune regulatory functions and are already activated in utero. To test the hypothesis that NKT cells are part of the regulatory network that sets the fetal Th2 predominance, percentages of V?24(+)V?11(+) NKT cells expressing Th1/Th2-related chemokine receptors (CKR) were assessed in cord blood. Furthermore, IL-4 and IFN-...    »
Journal title abbreviation:
PLoS ONE
Year:
2011
Journal volume:
6
Journal issue:
1
Pages contribution:
e15714
Language:
eng
Print-ISSN:
1932-6203
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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