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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Wohn, Christian; Ober-Blöbaum, Julia L; Haak, Stefan; Pantelyushin, Stanislav; Cheong, Cheolho; Zahner, Sonja P; Onderwater, Sabina; Kant, Marius; Weighardt, Heike; Holzmann, Bernhard; Reizis, Boris; Becher, Burkhard; Prens, Errol P; Clausen, Björn E 
Title:
Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice. 
Abstract:
Psoriasis is an autoinflammatory skin disease of unknown etiology. Topical application of Aldara cream containing the Toll-like receptor (TLR)7 agonist Imiquimod (IMQ) onto patients induces flares of psoriasis. Likewise, in mice IMQ triggers pathological changes closely resembling psoriatic plaque formation. Key cytokines like IL-23 and type-I IFN (IFN-I), both being produced mainly by dendritic cells (DCs), have been implicated in psoriasis. Although plasmacytoid DCs (pDCs) are the main source...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2013 
Journal volume:
110 
Journal issue:
26 
Pages contribution:
10723-8 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0027-8424 
TUM Institution:
Chirurgische Klinik und Poliklinik; Molekulare Allergologie (Prof. Schmidt-Weber)