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- Document type:
- Journal Article
- Author(s):
- Weissbrich, Bianca; Nauerth, Magdalena; Busch, Dirk H
- Title:
- Adoptive immunotherapy: New assay for the identification of T cells with optimal avidity.
- Abstract:
- T cells expressing high avidity T-cell receptors (TCRs) have been shown to mediate superior therapeutic effects. A novel koff-rate assay allows for the quantitative and reproducible assessment of the avidity of TCRs for their ligands directly on living T cells, ex vivo. This assay might facilitate the selection of T cells with an optimal avidity for their target, hence favoring the development of adoptive immunotherapeutic regimens.
- Journal title abbreviation:
- Oncoimmunology
- Year:
- 2013
- Journal volume:
- 2
- Journal issue:
- 10
- Pages contribution:
- e26199
- Language:
- eng
- Fulltext / DOI:
- doi:10.4161/onci.26199
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/24244903
- Print-ISSN:
- 2162-4011
- TUM Institution:
- Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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