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Document type:
Journal Article; Article 
Author(s):
Orabi, Ahmed; Bieringer, Maria; Geerlof, Arie; Bruss, Volker 
Title:
An Aptamer against the Matrix Binding Domain on the Hepatitis B Virus Capsid Impairs Virion Formation. 
Abstract:
The hepatitis B virus (HBV) particle is an icosahedral nucleocapsid surrounded by a lipid envelope containing viral surface proteins. A small domain (matrix domain [MD]) in the large surface protein L and a narrow region (matrix binding domain [MBD]) including isoleucine 126 on the capsid surface have been mapped, in which point mutations such as core I126A specifically blocked nucleocapsid envelopment. It is possible that the two domains interact with each other during virion morphogenesis. By...    »
 
Journal title abbreviation:
J Virol 
Year:
2015 
Journal volume:
89 
Journal issue:
18 
Pages contribution:
9281-7 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-538X 
TUM Institution:
Institut für Virologie 
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