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Dokumenttyp:
Journal Article; Article 
Autor(en):
Ahles, Andrea; Rodewald, Fabian; Rochais, Francesca; Bünemann, Moritz; Engelhardt, Stefan 
Titel:
Interhelical interaction and receptor phosphorylation regulate the activation kinetics of different human ?1-adrenoceptor variants. 
Abstract:
G protein-coupled receptors represent the largest class of drug targets, but genetic variation within G protein-coupled receptors leads to variable drug responses and, thereby, compromises their therapeutic application. One of the most intensely studied examples is a hyperfunctional variant of the human ?1-adrenoceptor that carries an arginine at position 389 in helix 8 (Arg-389-ADRB1). However, the mechanism underlying the higher efficacy of the Arg-389 variant remained unclear to date. Despite...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2015 
Band / Volume:
290 
Heft / Issue:
Seitenangaben Beitrag:
1760-9 
Sprache:
eng 
Volltext / DOI:
Print-ISSN:
0021-9258 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie