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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Beyerle, A; Braun, A; Banerjee, A; Ercal, N; Eickelberg, O; Kissel, TH; Stoeger, T
Titel:
Inflammatory responses to pulmonary application of PEI-based siRNA nanocarriers in mice.
Abstract:
Polymeric non-viral vector systems for pulmonary application of siRNA are promising carriers, but have failed to enter clinical trials because of safety and efficiency problems. Therefore, improving their transfection efficiency, as well as their toxicological profile, is the subject of intensive research efforts. Six different poly(ethylene imine) (PEI)-based nanocarriers, with hydrophilic and hydrophobic PEG modifications, were toxicologically evaluated for pulmonary application in mice. Nanoc...    »
Zeitschriftentitel:
Biomaterials
Jahr:
2011
Band / Volume:
32
Heft / Issue:
33
Seitenangaben Beitrag:
8694-701
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.biomaterials.2011.07.082
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21855131
Print-ISSN:
0142-9612
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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