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Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Weickert, Marie-Theresa; Hecker, Judith S; Buck, Michèle C; Schreck, Christina; Rivière, Jennifer; Schiemann, Matthias; Schallmoser, Katharina; Bassermann, Florian; Strunk, Dirk; Oostendorp, Robert A J; Götze, Katharina S
Title:
Bone marrow stromal cells from MDS and AML patients show increased adipogenic potential with reduced Delta-like-1 expression.
Abstract:
Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal hematopoietic stem cell disorders with a poor prognosis, especially for elderly patients. Increasing evidence suggests that alterations in the non-hematopoietic microenvironment (bone marrow niche) can contribute to or initiate malignant transformation and promote disease progression. One of the key components of the bone marrow (BM) niche are BM stromal cells (BMSC) that give rise to osteoblasts and adipocytes. It has b...    »
Journal title abbreviation:
Sci Rep
Year:
2021
Journal volume:
11
Journal issue:
1
Print-ISSN:
2045-2322
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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