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Document type:
Journal Article; Article 
Author(s):
Kirschner, Andreas; Thiede, Melanie; Grünewald, Thomas G P; Alba Rubio, Rebeca; Richter, Günther H S; Kirchner, Thomas; Busch, Dirk H; Burdach, Stefan; Thiel, Uwe 
Title:
Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo. 
Abstract:
Pregnancy-associated plasma protein-A (PAPPA), also known as pappalysin, is a member of the insulin-like growth factor (IGF) family. PAPPA acts as a protease, cleaving IGF inhibitors, i.e., IGF binding proteins (IGFBPs), thereby setting free IGFs. The insulin/IGF-axis is involved in cancer in general and in Ewing sarcoma (ES) in particular. ES is a highly malignant bone tumor characterized by early metastatic spread. PAPPA is associated with various cancers. It is overexpressed and required for...    »
 
Journal title abbreviation:
Oncoimmunology 
Year:
2017 
Journal volume:
Journal issue:
Pages contribution:
e1273301 
Language:
eng 
Print-ISSN:
2162-4011 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin